Getting the “Kill” into “Shock and Kill”: Strategies to Eliminate Latent HIV

Modeling Kick-Kill Strategies toward HIV Cure

Although combinatorial antiretroviral therapy (cART) potently suppresses the virus, a sterile or functional cure still remains one of the greatest therapeutic challenges worldwide. Reservoirs are infected cells that can maintain HIV persistence for several years in patients with optimal cART, which is a leading obstacle to eradicate the virus. Despite the significant progress that has been made...

Die to kill: psychological and sociological study of suicide terrorism

One of the principal challenges now days, especially in the countries which are engaged in inland riots, is suicide attack which spreads fear broadly in human societies. More than the legal and political reactions to this social phenomenon, one of the preventive ways, is to analyze the suicide terrorists personally. No doubt, achievement to this understanding can be influential in preventing th...

DNA vaccines and apoptosis: to kill or not to kill?

The Journal of Clinical Investigation | July 2003 | Volume 112 | Number 1 RNase. Proc. Natl. Acad. Sci. U. S. A. 100:4102-4107. 14. Shinkura, R., et al. 2003. The influence of transcriptional orientation on endogenous switch region function. Nat. Immunol. 4:435–441. 15. Yu, K., Chedin, F., Hsieh, C.L., Wilson, T.E., and Lieber, M.R. 2003. R-loops at immunoglobulin class switch regions in the ch...

Do genes allow inflammation to kill or not to kill?

A lysin to kill

An enzyme produced by a bacteriophage can enter human cells and kill intracellular Streptococcus pyogenes.